ATVB in Focus Metabolic Syndrome and Insulin Resistance: Mechanisms and Consequences

American Heart Association: 9/1/12. Metabolic syndrome (MetS), a clustering of risk factors for type 2 diabetes mellitus and cardiovascular disease, has been associated with cognitive dysfunction and brain abnormalities. This review describes the literature on the impact of MetS on brain and cognition and suggests directions for future research. A literature search for reports of MetS […]

Poor Long-Term Blood Pressure Control After Intracerebral Hemorrhage

American Heart Association: August 16, 2012 Hypertension is the most important risk factor associated with intracerebral hemorrhage. We explored racial differences in blood pressure (BP) control after intracerebral hemorrhage and assessed predictors of BP control at presentation, 30 days, and 1 year in a prospective cohort study. Methods—Subjects with spontaneous intracerebral hemorrhage were identified from the […]

Simple Science @Heart: Black stroke survivors face greater risk from high blood pressure

Blog.heart.org: 8/16/12 Blacks who survive strokes caused by bleeding in the brain are more likely than whites to have high blood pressure a year later, a new study says. Continued high blood pressure increases their risk of another stroke. The study examined racial and ethnic differences in these strokes, called intracranial hemorrhage or ICH. They make up only 10 percent […]

ATVB in Focus Metabolic Syndrome and Insulin Resistance: Mechanisms and Consequences

atvb.ahajournals.org: 9/1/12 Insulin resistance is a characteristic feature of obesity and type 2 diabetes mellitus and impacts the heart in various ways. Impaired insulin-mediated glucose uptake is a uniformly observed characteristic of the heart in these states, although changes in upstream kinase signaling are variable and dependent on the severity and duration of the associated obesity […]

Diabetes and death

hhs.gov: August 21, 2012. From the U.S. Department of Health and Human Services, I’m Nicholas Garlow with HHS HealthBeat. More people have diabetes now than ever before. People with diabetes often have other health risk factors, like obesity and high blood pressure. But data from the National Health Interview Survey shows that death rates are declining […]

Translating the Research in Insulin Injection Technique

tde.sagepub.com: August 15, 2012. Glucose variability leading to suboptimal glycemic control is common among people using injection therapies. Advanced technology and new studies have identified important issues related to injection technique: needle length and gauge, body mass index, skin and subcutaneous tissue thickness, adequate resuspension of cloudy insulins, leakage, choice of injection site and rotation, pinching […]

Supporting self-management after attending a structured education programme: a qualitative longitudinal investigation of type 1 diabetes patients¿ experiences and views

biomedcentral.com: 8/14/12 Structured education programmes for patients with diabetes and other chronic conditions are being widely adopted. However, follow-up studies suggest that course graduates may struggle to sustain the self-care practices taught on their courses over time. This study explored the support needs of patients with type 1 diabetes after attending a structured education programme promoting […]

Outcomes with various drug eluting or bare metal stents in patients with diabetes mellitus: mixed treatment comparison analysis of 22 844 patient years of follow-up from randomised trials

bmj.com: August 10, 2012 To evaluate the efficacy and safety of currently used drug eluting stents compared with each other and compared with bare metal stents in patients with diabetes. Design Mixed treatment comparison meta-analysis. Data sources and study selection PubMed, Embase, and CENTRAL were searched for randomised clinical trials, until April 2012, of four durable polymer drug […]

Accelerating the Development of New Drugs and Diagnostics: Maximizing the Impact of the Cures Acceleration Network – Workshop Summary

Iom.edu: August 22, 2012. Advances in technologies and knowledge are creating new avenues for research and opportunities for the discovery and clinical development of innovative therapies and diagnostics. However, despite these opportunities, only a small fraction of investigational products are successfully developed into cures and therapies that can be accessed by patients. One response to the […]

The Value of Statistical Analysis Plans in Observational Research

Jama.jamanetwork: August 22/29, 2012 The increasing availability of electronic health data combined with federal investment has stimulated an expansion in observational clinical research.1 Observational studies can complement clinical trials and provide important information about comparative safety and effectiveness in populations not well studied in clinical trials. However, there are numerous examples in which the findings from observational […]

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