Racial differences in albuminuria, kidney function, and risk of stroke

Neurology.org: September 19, 2012 The objective of this study was to examine the joint associations of estimated glomerular filtration rate (eGFR) and urinary albumin excretion with incident stroke in a large national cohort study. Methods: Associations of urinary albumin to creatinine ratio (ACR) and eGFR with incident stroke were examined in 25,310 participants of the Reasons for […]

Emotional neglect in childhood and cerebral infarction in older age

Neurology.org: September 19, 2012 The purpose of the study was to test the hypothesis that a higher level of childhood adversity is associated with increased risk of cerebral infarction in old age. Methods: Older participants in a longitudinal clinical–pathologic study rated adverse childhood experiences (e.g., emotional neglect, parental intimidation and violence) on a previously established 16-item scale. […]

Association Between Omega-3 Fatty Acid Supplementation and Risk of Major Cardiovascular Disease Events

A Systematic Review and Meta-analysis Jama.jamanetwork.com: 9/12/12 Objective  To assess the role of omega-3 supplementation on major cardiovascular outcomes. Data Sources  MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials through August 2012. Study Selection  Randomized clinical trials evaluating the effect of omega-3 on all-cause mortality, cardiac death, sudden death, myocardial infarction, and stroke. Data […]

Identifying Research Needs for Improving Health Care

The American College of Physicians: September 18, 2012. Insights from systematic reviews can help new studies better meet the priorities and needs of patients and communities. However, systematic reviews unfortunately have not yet achieved this position to direct and guide new research studies. The Agency for Healthcare Research and Quality’s Evidence-based Practice Center Program uses […]

Influence of Reported Study Design Characteristics on Intervention Effect Estimates From Randomized, Controlled Trials

The American College of Physicians: September 18, 2012. Published evidence suggests that aspects of trial design lead to biased intervention effect estimates, but findings from different studies are inconsistent. This study combined data from 7 meta-epidemiologic studies and removed overlaps to derive a final data set of 234 unique meta-analyses containing 1973 trials. Outcome measures […]

Can We Depend on Investigators to Identify and Register Randomized Controlled Trials?

Plosone.org: 9/11/12 To reduce publication bias, systematic reviewers are advised to search conference abstracts to identify randomized controlled trials (RCTs) conducted in humans and not published in full. We assessed the information provided by authors to aid identification of RCTs for reviews. Methods We handsearched the Association for Research in Vision and Ophthalmology (ARVO) meeting abstracts […]

Estimating treatment effects from a randomized clinical trial in the presence of a secondary treatment

Biostatistics.oxfordjournals.org: 4/17/12 In randomized clinical trials involving survival time, a challenge that arises frequently, for example, in cancer studies (Manegold, Symanowski, Gatzemeier, Reck, von Pawel, Kortsik, Nackaerts, Lianes and Vogelzang, 2005. Second-line (post-study) chemotherapy received by patients treated in the phase III trial of pemetrexed plus cisplatin versus cisplatin alone in malignant pleural mesothelioma. Annals of […]

A valid formulation of the analysis of noninferiority trials under random effects meta-analysis

Biostatistics.oxfordjournals.org: 3/30/12 A noninferiority (NI) trial is sometimes employed to show efficacy of a new treatment when it is unethical to randomize current patients to placebo because of the established efficacy of a standard treatment. Under this framework, if the NI trial determines that the treatment advantage of the standard to the new drug (i.e. S−N) […]

How doctors and hospitals have collected billions in questionable Medicare fees

Publicintegrity.org: September 15, 2012 Center investigation suggests costs from upcoding and other abuses likely top $11 billion Thousands of doctors and other medical professionals have steadily billed higher rates for treating elderly patients on Medicare over the last decade — adding $11 billion or more to their fees and signaling a possible rise in medical billing […]

Hospital Readmission Rates Dropping Slightly, New Study Finds

Capsules.kaiserhealthnews.org: By Jordan Rau SEPTEMBER 14TH, 2012, 11:44 AM A new government analysis has found that hospital readmission rates of Medicare patients have fallen more than previously reported, bolstering hope that hospitals are having some success at tackling this stubborn and expensive problem. Hospital readmissions have been getting extensive attention as a new penalty program kicks in […]

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